9.Of urgent concern is the fact that many plant species, communities, and their ecological interactions, including the many relationships between plant species and human communities and cultures, are in danger of extinction, threatened by such human-induced factors as, inter alia, climate change, habitat loss and transformation, over-exploitation, alien invasive species, pollution, clearing for agriculture and other development,. If this loss is not stemmed, countless opportunities to develop new solutions to pressing economic, social, health and industrial problems will also be lost. Furthermore, plant diversity is of special concern to indigenous and local communities, and these communities have a vital role to play in addressing the loss of plant diversity.